Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ubash3atm1Jni
Name:	ubiquitin associated and SH3 domain containing, A; targeted mutation 1, James N Ihle
MGI ID:	MGI:3051962
Synonyms:	Sts2-, Tula-
Gene:	Ubash3a  Location: Chr17:31426847-31465866 bp, + strand  Genetic Position: Chr17, 15.84 cM
Alliance:	Ubash3atm1Jni page

Germline Transmission:	Earliest citation of germline transmission: J:89761
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: An 11 kb fragment of sequence containing exons 6, 7 and part of 8 was replaced with a neomycin resistance gene. Southern blot confirmed correct targeting and Northern blot demonstrated an absence of mRNA in homozygotes. Western blot indicated absence of protein in mutants. (J:89761)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ubash3a Mutation:	32 strains or lines available

Original:	J:89761 Carpino N, et al., Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2. Immunity. 2004 Jan;20(1):37-46
All:	12 reference(s)