Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Psen1tm1Shs
Name:	presenilin 1; targeted mutation 1, Takuji Shirasawa
MGI ID:	MGI:3051523
Synonyms:	PS-1-
Gene:	Psen1  Location: Chr12:83734926-83781869 bp, + strand  Genetic Position: Chr12, 38.84 cM
Alliance:	Psen1tm1Shs page

Germline Transmission:	Earliest citation of germline transmission: J:91975
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: The alternatively spliced variant of human Psen-1-374 and a tk-neo cassette were inserted into exon 9. Southern blot and PCR confirmed the mutant allele. Psen-1 mRNA was not detected by Northern blot analysis of mutant mice. Western blot detected no full length or truncated protein. (J:91975)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	38 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Psen1 Mutation:	46 strains or lines available

Original:	J:91975 Yuasa S, et al., Impaired cell cycle control of neuronal precursor cells in the neocortical primordium of presenilin-1-deficient mice. J Neurosci Res. 2002 Nov 1;70(3):501-13
All:	6 reference(s)