Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Plxnd1tm1Joe
Name:	plexin D1; targeted mutation 1, Jonathan A Epstein
MGI ID:	MGI:3050678
Synonyms:	plexinD1-
Gene:	Plxnd1  Location: Chr6:115931772-115971966 bp, - strand  Genetic Position: Chr6, 53.72 cM
Alliance:	Plxnd1tm1Joe page

Germline Transmission:	Earliest citation of germline transmission: J:91658
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The first coding exon, containing the sema domain, was replaced with a floxed neo. Southern blot demonstrated correct targeting. In situ hybridization and immunohistochemistry indicated lack of transcript and protein, respectively, in mutant embryos and hearts. (J:91658)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	10 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Plxnd1 Mutation:	86 strains or lines available

Original:	J:91658 Gitler AD, et al., PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development. Dev Cell. 2004 Jul;7(1):107-16
All:	8 reference(s)