Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cd151tm1Lka
Name:	CD151 antigen; targeted mutation 1, Leonie K Ashman
MGI ID:	MGI:3050539
Synonyms:	CD151-
Gene:	Cd151  Location: Chr7:141047305-141051386 bp, + strand  Genetic Position: Chr7, 86.82 cM
Alliance:	Cd151tm1Lka page

Germline Transmission:	Earliest citation of germline transmission: J:91605
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: A loxP site was inserted in the intron between exons 1c and 2 and a floxed neo cassette downstream of exon 7. Crossing with mice expressing Cre in the germ line excised exons 2-7 and the neo. Southern blot confirmed recombination and Northern blot and reverse transcription-PCR indicated lack of transcript in mutants. (J:91605)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Cd151 Mutation:	34 strains or lines available

Original:	J:91605 Wright MD, et al., Characterization of mice lacking the tetraspanin superfamily member CD151. Mol Cell Biol. 2004 Jul;24(13):5978-88
All:	11 reference(s)