Tg(HBB-cre)27053Kpe
Transgene Detail
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Symbol: |
Tg(HBB-cre)27053Kpe |
Name: |
transgene insertion 27053, Kenneth Peterson |
MGI ID: |
MGI:3050350 |
Synonyms: |
Tg(HBB-cre)27053Tpa |
Transgene: |
Tg(HBB-cre)27053Kpe Location: unknown
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Alliance: |
Tg(HBB-cre)27053Kpe page
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Strain of Origin: |
Not Specified
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Transgene Type: |
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Transgenic (Recombinase) |
Mutation: |
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Insertion
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Tg(HBB-cre)27053Kpe expression driven by
1 gene
Transgene expression driven by:
Organism |
Driver Gene |
Homolog in Mouse |
Note |
human |
HBB (3043) |
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Mutation details: This transgene expresses Cre recombinase under the control of a human beta-globin gene promoter and a beta-globin locus control region (LCR). The inserted copy number was determined to be 2. Expression of Cre was determined by crosses to a reporter strain, and was shown to be present in the erythroid compartment throughout development, including the yolk sac during primitive erythropoiesis, the liver during fetal definitive erythropoiesis and the bone marrow during adult definitive erythropoiesis. Cre activity was also noted in the peripheral circulation during development, in the adult liver and in some megakaryocytes. No expression in the germ line was detected.
(J:89725)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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HBB
(human)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:89725 Peterson KR, et al., Transgenic Cre expression mice for generation of erythroid-specific gene alterations. Genesis. 2004 May;39(1):1-9 |
All: |
1 reference(s) |
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