Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Kcnma1tm1Ruth
Name:	potassium large conductance calcium-activated channel, subfamily M, alpha member 1; targeted mutation 1, P Ruth
MGI ID:	MGI:3050114
Synonyms:	BK-, BKalpha-, BK-KO, BK L1
Gene:	Kcnma1  Location: Chr14:23342356-24055173 bp, - strand  Genetic Position: Chr14, 12.92 cM
Alliance:	Kcnma1tm1Ruth page

Germline Transmission:	Earliest citation of germline transmission: J:91427
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A single loxp site was inserted upstream of the exon encoding the pore-forming alpha subunit, and a floxed neo-TK cassette downstream. Transient cre-expression excised the floxed region including the exon and neo-TK. Southern blot and PCR confirmed recombination and Western blot of brain membrane proteins from mutants indicated absence of the C-terminus of the alpha subunit. (J:91427)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kcnma1 Mutation:	101 strains or lines available

Original:	J:91427 Sausbier M, et al., Cerebellar ataxia and Purkinje cell dysfunction caused by Ca2+-activated K+ channel deficiency. Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9474-8
All:	30 reference(s)