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Gene Expression Data
Assay Details
Assay
Reference: J:90613 Dreyer SD, et al., Lmx1b expression during joint and tendon formation: localization and evaluation of potential downstream targets. Gene Expr Patterns. 2004 Jul;4(4):397-405
Assay type: RNA in situ
MGI Accession ID: MGI:3047637
Gene symbol: Lmx1b
Gene name: LIM homeobox transcription factor 1 beta
Probe: Lmx1b cDNA4
Probe preparation: Antisense labelled with S35 RNA
Visualized with: Autoradiography
Results
Specimen 1B: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: future leg mesenchyme Very strong Graded 1B Expression is in the dorsal mesoderm with a proximal-distal gradient where the stronger expression was located toward the distal tip.

Specimen 2B: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: hindlimb mesenchyme Present Regionally restricted 2B Expression is in tendons and joints.
TS21: knee joint primordium Present Regionally restricted 2B Expression is in the dorsal aspects, the dorsal perichondrium and the primordial tendon.
TS21: femur cartilage condensation Absent 2B
TS21: hindlimb musculature Absent 2B
TS21: tibia-fibula pre-cartilage condensation Absent 2B

Specimen 2F: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: knee joint primordium Weak 2F

Specimen 2J: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: patella pre-cartilage condensation Trace 2J
TS23: hindlimb mesenchyme Present Regionally restricted 2J Expression is in the distal autopod.

Specimen 3D: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: hindlimb mesenchyme Present Regionally restricted 3D Expression is in the developing tendon and the condensed mesoderm surrounding the muscle.
TS21: hindlimb musculature Absent 3D

Specimen 4B, D/V: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: forelimb digit Very strong Regionally restricted 4B Expression is at the distal undifferentiated dorsal mesenchyme and proximally in the tendon primordia and joint-associated tissues.

Specimen 4D, A/P: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: forelimb digit Very strong Regionally restricted 4D Expression is accentuated at the distal end of each phalanx.

Specimen 4F, D/V: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: forelimb digit Present Regionally restricted 4F Expression is at the distal undifferentiated dorsal mesenchyme and proximally in the tendon primordia and joint-associated tissues.

Specimen 4H, A/P: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: forelimb digit Present Regionally restricted 4H Expression is accentuated at the distal end of each phalanx.

Specimen 4J, D/V: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: forelimb digit Weak Regionally restricted 4J Expression is at the distal undifferentiated dorsal mesenchyme and proximally in the tendon primordia and joint-associated tissues.

Specimen 4L, A/P: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: forelimb digit Weak Regionally restricted 4L Expression is accentuated at the distal end of each phalanx.

Specimen 4N, D/V: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: forelimb digit Absent 4N

Specimen 4P, A/P: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: forelimb digit Absent 4P

Specimen Not Shown: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: hindlimb digit Present Regionally restricted Expression is at the distal undifferentiated dorsal mesenchyme and proximally in the tendon primordia and joint-associated tissues. Expression is accentuated at the distal end of each phalanx.

Specimen Not Shown: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: hindlimb digit Present Regionally restricted Expression is at the distal undifferentiated dorsal mesenchyme and proximally in the tendon primordia and joint-associated tissues. Expression is accentuated at the distal end of each phalanx.

Specimen Not Shown: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: hindlimb digit Weak Regionally restricted Expression is at the distal undifferentiated dorsal mesenchyme and proximally in the tendon primordia and joint-associated tissues. Expression is accentuated at the distal end of each phalanx.

Specimen Not Shown: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: hindlimb digit Absent

Specimen 5B: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: forelimb digit Present Regionally restricted 5B Expression is in the distal undifferentiated dorsal mesoderm.

Specimen 5E: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: forelimb digit Present Regionally restricted 5E Expression is in the distal undifferentiated dorsal mesoderm.

Specimen 6E: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: limb digit Present Regionally restricted 6E Expression is in the dorsal joint-forming region.

Specimen 6F: embryonic day 14.5; Lmx1btm1Rjo/Lmx1btm1Rjo (more )
Structure Level Pattern Image Note
TS22: limb digit Present 6F The authors did not describe the expression in this mutant.

Specimen 6G: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: limb digit Present Regionally restricted 6G

Specimen 6H: embryonic day 14.5; Lmx1btm1Rjo/Lmx1btm1Rjo (more )
Structure Level Pattern Image Note
TS22: limb digit Present 6H The authors did not describe the expression in this mutant.

Specimen 7B: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: limb digit Present Regionally restricted 7B Expression is in the joints.

Specimen 7G: embryonic day 15.5; Lmx1btm1Rjo/Lmx1btm1Rjo (more )
Structure Level Pattern Image Note
TS23: limb digit Present 7G The authors did not describe the expression in this mutant.


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory