Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Srftm1Zli
Name:	serum response factor; targeted mutation 1, Zhenlin Li
MGI ID:	MGI:3046779
Synonyms:	Sf, Srf-flex2neo, Srfflx
Gene:	Srf  Location: Chr17:46859255-46867101 bp, - strand  Genetic Position: Chr17, 22.9 cM
Alliance:	Srftm1Zli page

Germline Transmission:	Earliest citation of germline transmission: J:91025
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: LoxP sites were inserted around exon 2 and after a PGK-neo cassette in intron 2 via homologous recombination. Western blot analysis confirmed protein expression from the mutant allele (J:91025)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	67 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Srf Mutation:	25 strains or lines available

Original:	J:91025 Parlakian A, et al., Targeted inactivation of serum response factor in the developing heart results in myocardial defects and embryonic lethality. Mol Cell Biol. 2004 Jun;24(12):5281-9
All:	25 reference(s)