Summary | Mutation origin | Mutation description | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Ighatm1(Myc)Janz
Name:	immunoglobulin heavy constant alpha; targeted mutation 1, Siegfried Janz
MGI ID:	MGI:3046399
Synonyms:	c-myc-KICalpha, IgH-MycCα, IgH-MycCalpha, iMycCalpha
Gene:	Igha  Location: Chr12:113219824-113223856 bp, - strand  Genetic Position: Chr12, 62.09 cM
Alliance:	Ighatm1(Myc)Janz page

Germline Transmission:	Earliest citation of germline transmission: J:90901
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Inserted expressed sequence) Mutation:    Insertion   Ighatm1(Myc)Janz expresses 1 gene Knock-in expresses: Organism Expressed Gene Note mouse Myc (MGI:97250)   Mutation details: A construct consisting of a 1.5 kb segment of genomic 5' flanking sequence from the mouse Myc gene with the P1/P2 promoters, the first noncoding exon, a mouse Myc intron-less cDNA clone with an in-frame 6x histidine tag sequence on the 3' end, a short segment of the 3' UTR including the major polyadenylation signal, and a loxP site flanked neomycin resistance gene cassette was inserted in opposite transcriptional orientation into intron 1 of the C alpha locus via homologous recombination. The neo cassette was subsequently removed by mating to cre transgenic mice. (J:90901)

View phenotypes and curated references for all genotypes (concatenated display).

List all tumor models in MMHCdb carrying Ighatm1(Myc)Janz

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Igha Mutation:	16 strains or lines available

Original:	J:90901 Cheung WC, et al., Novel targeted deregulation of c-Myc cooperates with Bcl-X(L) to cause plasma cell neoplasms in mice. J Clin Invest. 2004 Jun;113(12):1763-73
All:	12 reference(s)