Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Slc5a7tm1Rbl
Name:	solute carrier family 5 (choline transporter), member 7; targeted mutation 1, Randy D Blakely
MGI ID:	MGI:3045463
Synonyms:	CHT-
Gene:	Slc5a7  Location: Chr17:54580618-54606062 bp, - strand  Genetic Position: Chr17, 28.23 cM, cytoband D
Alliance:	Slc5a7tm1Rbl page

Germline Transmission:	Earliest citation of germline transmission: J:90846
Parent Cell Line:	TL1/TL-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: EGFP and Neo cassettes replaced part of the coding region beginning at the ATG in exon two and extending into intron 4. LoxP sites flanked the EGFP and FRT sites flanked the neo. Southern blot and PCR confirmed recombination in mutants and western blot indicated a reduction of protein levels in heterozygous mice and the absence of protein immunoactivity in the homozygous mutants. (J:90846)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc5a7 Mutation:	42 strains or lines available

Original:	J:90846 Ferguson SM, et al., Lethal impairment of cholinergic neurotransmission in hemicholinium-3-sensitive choline transporter knockout mice. Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8762-7
All:	7 reference(s)