Tg(Fabp4-SREBP1a)1Reh
Transgene Detail
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| Symbol: |
Tg(Fabp4-SREBP1a)1Reh |
| Name: |
transgene insertion 1, Robert E Hammer |
| MGI ID: |
MGI:3045406 |
| Synonyms: |
A line, aP2-nSREBP-1a |
| Transgene: |
Tg(Fabp4-SREBP1a)1Reh Location: unknown
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| Alliance: |
Tg(Fabp4-SREBP1a)1Reh page
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| Strain of Origin: |
Not Specified
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Fabp4-SREBP1a)1Reh expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
SREBF1 (6720) |
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Mutation details: This transgene overexpresses a transcriptionally active fragment of the human SREBP-1a gene under the control of a mouse adipose-specific promoter/enhancer of the Fabp4 gene. This truncated form of the SREBP-1a gene lacks the membrane attachment domain and translocates to the nucleus without proteolytic processing. Northern blot analysis demonstrated that the transgene was abundantly expressed in both white and brown adipose tissue.
(J:85534)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:85534 Horton JD, et al., Overexpression of sterol regulatory element-binding protein-1a in mouse adipose tissue produces adipocyte hypertrophy, increased fatty acid secretion, and fatty liver. J Biol Chem. 2003 Sep 19;278(38):36652-60 |
| All: |
1 reference(s) |
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Analysis Tools
