Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Smad1tm1Sor
Name:	SMAD family member 1; targeted mutation 1, Philippe Soriano
MGI ID:	MGI:3045218
Synonyms:	Smad1C
Gene:	Smad1  Location: Chr8:80065024-80126057 bp, - strand  Genetic Position: Chr8, 37.56 cM
Alliance:	Smad1tm1Sor page

Germline Transmission:	Earliest citation of germline transmission: J:90769
Parent Cell Line:	AK7 (ES Cell)
Strain of Origin:	129S4/SvJaeSor

Allele Type:    Targeted (Not Specified) Mutations:    Insertion, Nucleotide substitutions   Mutation details: A floxed neo was introduced upstream of exon 7, and within exon 7 the C-terminal SSVS motif was changed to AAVA. Cre-mediated recombination excised the neo, leaving the mutated exon 7. Western blot of embryonic protein extracts indicated that mutant embryos showed similar levels of protein as that in wild-type. (J:90769)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Smad1 Mutation:	32 strains or lines available

Original:	J:90769 Aubin J, et al., In vivo convergence of BMP and MAPK signaling pathways: impact of differential Smad1 phosphorylation on development and homeostasis. Genes Dev. 2004 Jun 15;18(12):1482-94
All:	1 reference(s)