Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Fgf15tm1Sms Name: fibroblast growth factor 15; targeted mutation 1, Suzanne L Mansour MGI ID: MGI:3044957 Gene: Fgf15  Location: Chr7:144450269-144454690 bp, + strand  Genetic Position: Chr7, 88.92 cM Alliance: Fgf15tm1Sms page

Fgf15tm1Sms/Fgf15tm1Sms mice display cardiovascular defects Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:90407
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The coding region of exon 3, which is the last coding exon, was replaced with a neomycin selection cassette inserted by homologous recombination. RT-PCR analysis of homozygous mutant embryos indicated an absence of normal transcript, but identified a mutant transcript containing exons 1 and 2. The mutant transcript lacks exon 3 sequence and therefore does not encode the putative HSPG and FGFR binding sites. (J:90407)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fgf15 Mutation:	15 strains or lines available

Original:	J:90407 Wright TJ, et al., Mouse FGF15 is the ortholog of human and chick FGF19, but is not uniquely required for otic induction. Dev Biol. 2004 May 1;269(1):264-75
All:	25 reference(s)