Tg(Vil-KRAS*G12V)#Syr
Transgene Detail
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| Symbol: |
Tg(Vil-KRAS*G12V)#Syr |
| Name: |
transgene insertion, Sylvie Robine |
| MGI ID: |
MGI:3044596 |
| Synonyms: |
Fo47, Fo33, K-rasV12G |
| Transgene: |
Tg(Vil-KRAS*G12V)#Syr Location: unknown
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| Alliance: |
Tg(Vil-KRAS*G12V)#Syr page
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| Strain of Origin: |
C57BL/6 x DBA/2
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Vil-KRAS*G12V)#Syr expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
KRAS (3845) |
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Transgene codes for a protein with a valine to glycine mutation. |
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Mutation details: The human K-ras gene with a mutation causing a change from glycine to valine at amino acid residue 12, is driven by the promoter for the mouse villin gene. 1-5 copies of the transgene were inserted in the genome. Transgene expression was detected in the small and large intestines and some in the kidney.
(J:77986)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:77986 Janssen KP, et al., Targeted expression of oncogenic K-ras in intestinal epithelium causes spontaneous tumorigenesis in mice. Gastroenterology. 2002 Aug;123(2):492-504 |
| All: |
9 reference(s) |
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Analysis Tools
