Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sqstm1tm1Jmos
Name:	sequestosome 1; targeted mutation 1, Jorge Moscat
MGI ID:	MGI:3043976
Synonyms:	p62-
Gene:	Sqstm1  Location: Chr11:50090193-50101654 bp, - strand  Genetic Position: Chr11, 30.36 cM, cytoband B1.2
Alliance:	Sqstm1tm1Jmos page

Germline Transmission:	Earliest citation of germline transmission: J:90010
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 1 was replaced with a neomycin selection cassette. Protein was undetected by Western blot analysis of homozygous mutant embryonic fibroblasts. (J:90010)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sqstm1 Mutation:	32 strains or lines available

Original:	J:90010 Duran A, et al., The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis. Dev Cell. 2004 Feb;6(2):303-9
All:	21 reference(s)