Tg(Trp53A135V)L2Ber
Transgene Detail
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| Symbol: |
Tg(Trp53A135V)L2Ber |
| Name: |
transgene insertion L2, Alan Bernstein |
| MGI ID: |
MGI:2447407 |
| Synonyms: |
pL53-2 |
| Transgene: |
Tg(Trp53A135V)L2Ber Location: unknown
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| Alliance: |
Tg(Trp53A135V)L2Ber page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Trp53A135V)L2Ber expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Note |
| mouse |
Trp53 (MGI:98834) |
Transgene codes for a protein with an alanine to valine mutation. |
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Mutation details: This transgene contains the mouse Trp53 (p53) promoter and an allele of the Trp53 gene that carries a point mutation in codon 135 (Ala135Val). Analysis showed the Trp53 promoter to drive high levels of expression in the spleen, thymus, lymph nodes, and ovaries. Transgenic expression was also detected in the lungs, liver, kidney, testis, and brain, while low levels were detected in skeletal muscle. Expression was undetected in the heart and blood.
(J:19870)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Lines L1, L2, and L3 were produced.
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| Original: |
J:19870 Lavigueur A, et al., High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene. Mol Cell Biol. 1989 Sep;9(9):3982-91 |
| All: |
2 reference(s) |
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Analysis Tools
