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Npc1l1tm1Swa
Targeted Allele Detail
Summary
Symbol: Npc1l1tm1Swa
Name: NPC1 like intracellular cholesterol transporter 1; targeted mutation 1, Scott W Altmann
MGI ID: MGI:3043784
Synonyms: NPC1L1(-)
Gene: Npc1l1  Location: Chr11:6161013-6180143 bp, - strand  Genetic Position: Chr11, 3.93 cM
Alliance: Npc1l1tm1Swa page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89712
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA lacZ-neomycin selection cassette replaced a genomic fragment containing bases 790 to 998 of the coding sequence of the gene. RT-PCR analysis on mucosal scrapings of homozygous mice confirmed that no detectable transcript was expressed from this allele. (J:89712)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Npc1l1 Mutation:  48 strains or lines available
References
Original:  J:89712 Altmann SW, et al., Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption. Science. 2004 Feb 20;303(5661):1201-4
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory