About   Help   FAQ
Ptpn22tm1Achn
Targeted Allele Detail
Summary
Symbol: Ptpn22tm1Achn
Name: protein tyrosine phosphatase, non-receptor type 22 (lymphoid); targeted mutation 1, Andrew C Chan
MGI ID: MGI:3043469
Synonyms: pep-, pep(E8)-
Gene: Ptpn22  Location: Chr3:103767111-103819563 bp, + strand  Genetic Position: Chr3, 45.52 cM, cytoband F3
Alliance: Ptpn22tm1Achn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:90029
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 8, encoding the phosphatase domain, was replaced with a neo cassette via homologous recombination. Immunoblot analysis confirmed the absence of wild-type or truncated protein in thymocytes and splenocytes from homozygotes. (J:90029)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptpn22 Mutation:  51 strains or lines available
References
Original:  J:90029 Hasegawa K, et al., PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells. Science. 2004 Jan 30;303(5658):685-9
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory