Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Scn1btm1Isom
Name:	sodium channel, voltage-gated, type I, beta; targeted mutation 1, Lori L Isom
MGI ID:	MGI:3043422
Synonyms:	Beta1 (-)
Gene:	Scn1b  Location: Chr7:30815949-30826428 bp, - strand  Genetic Position: Chr7, 19.3 cM
Alliance:	Scn1btm1Isom page

Germline Transmission:	Earliest citation of germline transmission: J:90136
Parent Cell Line:	Pat5 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 3 as well as the 73 bp of intron 3 that are required for the expression of the Beta1A embryonic splice variant were replaced by a neomycin cassette inserted by homologous recombination. Transcript was undetected in homozygous mutant mice by Northern blot analysis of brain RNA. (J:90136)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scn1b Mutation:	6 strains or lines available

Original:	J:90136 Chen C, et al., Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture. J Neurosci. 2004 Apr 21;24(16):4030-42
All:	20 reference(s)