Summary | Mutation origin | Mutation description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Mapttm1(Mecp2)Jae
Name:	microtubule-associated protein tau; targeted mutation 1, Rudolf Jaenisch
MGI ID:	MGI:3043293
Synonyms:	Tau-Mecp2 ki
Gene:	Mapt  Location: Chr11:104122216-104222916 bp, + strand  Genetic Position: Chr11, 67.79 cM, cytoband E1
Alliance:	Mapttm1(Mecp2)Jae page

Germline Transmission:	Earliest citation of germline transmission: J:89593
Parent Cell Line:	v6.5 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Allele Type:    Targeted (Inserted expressed sequence, Null/knockout) Mutation:    Insertion   Mapttm1(Mecp2)Jae expresses 1 gene Knock-in expresses: Organism Expressed Gene Note mouse Mecp2 (MGI:99918)   Mutation details: The mouse Mecp2 coding sequence, a modified Kozak sequence and a neo-cassette were placed in-frame into exon 1 of Mapt via homologous combination. The resulting fusion protein contained the first 31 amino acids of Mapt fused to Mecp2 and was highly expressed in the brain (in post-mitotic neurons), lung, and kidney. (J:89593)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mapt Mutation:	428 strains or lines available

Original:	J:89593 Luikenhuis S, et al., Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice. Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6033-8
All:	2 reference(s)