Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Angpt2tm1Gdy
Name:	angiopoietin 2; targeted mutation 1, George D Yancopoulos
MGI ID:	MGI:3040929
Synonyms:	Ang-2-, Ang2-, Ang-2/LacZ, Ang2LZ, Angpt2-
Gene:	Angpt2  Location: Chr8:18740279-18791578 bp, - strand  Genetic Position: Chr8, 10.3 cM
Alliance:	Angpt2tm1Gdy page

Germline Transmission:	Earliest citation of germline transmission: J:89618
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A lacZ and neo cassette was inserted into the first exon, deleting 310 bp of exon 1, spanning the translation initiation site and the first 257 bp (85 codons). Lack of transcript was confirmed by Northern blot of mutant heart, kidney and lung. Beta-galactosidase was expressed from this allele under the control of the endogenous promoter. (J:89618)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Angpt2 Mutation:	46 strains or lines available

Original:	J:89618 Gale NW, et al., Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1. Dev Cell. 2002 Sep;3(3):411-23
All:	22 reference(s)