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Klhl10tm1Zuk
Targeted Allele Detail
Summary
Symbol: Klhl10tm1Zuk
Name: kelch-like 10; targeted mutation 1, Martin M Matzuk
MGI ID: MGI:3040869
Gene: Klhl10  Location: Chr11:100332743-100347848 bp, + strand  Genetic Position: Chr11, 63.47 cM, cytoband D
Alliance: Klhl10tm1Zuk page
Disrupted spermatogenesis in Klhl10tm1Zuk chimeric mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Mouse Generated:  Earliest citation of chimera generation: J:89621
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Exon 1, containing the start codon, was deleted via homologous recombination. Northern blot analysis showed decreased expression in heterozygous stem cells. (J:89621)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Klhl10 Mutation:  16 strains or lines available
Notes
Haploinsufficiency of Klhl10 in male chimeras prevents genetic transmission of the mutated allele from males and increases the difficulty of generating non-chimeric heterozygous mice. Phenotype data reported are from chimeric male mice and a single heterozygous male generated from a female chimera.
References
Original:  J:89621 Yan W, et al., Haploinsufficiency of kelch-like protein homolog 10 causes infertility in male mice. Proc Natl Acad Sci U S A. 2004 May 18;101(20):7793-8
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
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