Tg(TagRb)1Plm Transgene Detail MGI Mouse (MGI:3040285)

Tg(TagRb)1Plm
Transgene Detail

Summary

Symbol:	Tg(TagRb)1Plm
Name:	transgene insertion 1, Pamela L Mellon
MGI ID:	MGI:3040285
Synonyms:	hLHBeta-Tag, hLHB-Tag, LHbeta-Tag, LHBETATAG, LHB-Tag, TAg-RB
Transgene:	Tg(TagRb)1Plm Location: unknown
Alliance:	Tg(TagRb)1Plm page

Transgene
origin

Strain of Origin:

(C57BL/6J x BALB/cJ)F2

Transgene
description

Transgene Type:		Transgenic (Inserted expressed sequence)
Mutation:		Insertion
		Mutation details: The transgene contains the human luteinizing hormone beta promoter and the wild-type alleles of the SV40 Tag and tag (large and small T antigen) genes. (J:10320)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(TagRb)1Plm

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Fifteen lines were produced. In this line mice developed bilateral ocular neoplasms at about five months of age. Retinal tumors were first observed at about 2 months, and filled the vitreous cavity by 5-6 months of age.

References

Original:	J:10320 Windle JJ, et al., Retinoblastoma in transgenic mice. Nature. 1990 Feb 15;343(6259):665-9
All:	27 reference(s)

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