Tg(IT6)5Kka
Transgene Detail
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| Symbol: |
Tg(IT6)5Kka |
| Name: |
transgene insertion 5, Kirsi Kananen |
| MGI ID: |
MGI:2446091 |
| Synonyms: |
inha/SV40 Tag, IT6, IT6-F |
| Transgene: |
Tg(IT6)5Kka Location: unknown
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| Alliance: |
Tg(IT6)5Kka page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Mutation details: 2.7 kb of SV40 sequences, including the large T and small t antigen coding regions and polyadenylation signal, were fused to a 6 kb mouse Inha promoter fragment and used for the transgene. RT-PCR analysis showed expression of the SV40 transgene in gonads, adrenal glands, brains, pituitary, spleen, kidney, epididymis, and submandibular gland.
(J:25047)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Two transgenic founders, designated IT6-M and IT6-F, were created. The expression pattern of both IT6-M and IT6-F were similar except for occasional expression in lungs and liver of IT6-F. Male mice developed spontaneous testicular tumors |
| Original: |
J:25047 Kananen K, et al., Gonadal tumorigenesis in transgenic mice bearing the mouse inhibin alpha-subunit promoter/simian virus T-antigen fusion gene: characterization of ovarian tumors and establishment of gonadotropin-responsive granulosa cell lines. Mol Endocrinol. 1995 May;9(5):616-27 |
| All: |
11 reference(s) |
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Analysis Tools
