Tg(IT2)4Kka
Transgene Detail
|
|
| Symbol: |
Tg(IT2)4Kka |
| Name: |
transgene insertion 4, Kirsi Kananen |
| MGI ID: |
MGI:2446096 |
| Synonyms: |
IT2 |
| Transgene: |
Tg(IT2)4Kka Location: unknown
|
| Alliance: |
Tg(IT2)4Kka page
|
|
|
|
| Transgene Type: |
|
Transgenic (Inserted expressed sequence) |
| Mutation: |
|
Insertion
|
| |
|
Mutation details: 2.7 kb of SV40 sequences, including the large T and small t antigen coding regions and polyadenylation signal, were fused to a small mouse Inha promoter fragment and used for the transgene. Transgene expression was confirmed by RT-PCR analysis.
(J:25047)
|
|
|
|
|
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
|
The transgene contains the mouse inhibin alpha promoter and the wild-type alleles of the SV40 Tag and tag (large and small T antigen) genes. The "IT2" construct carried a 2-kb fragment of the mouse inhibin alpha promoter.
RT-PCR analysis detected expression of the SV40 transgene in testis. This line did not develop gonadal tumors. ... |
| Original: |
J:25047 Kananen K, et al., Gonadal tumorigenesis in transgenic mice bearing the mouse inhibin alpha-subunit promoter/simian virus T-antigen fusion gene: characterization of ovarian tumors and establishment of gonadotropin-responsive granulosa cell lines. Mol Endocrinol. 1995 May;9(5):616-27 |
| All: |
2 reference(s) |
|
Analysis Tools
