Summary | Transgene origin | Transgene description | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | Notes | References

Symbol:	Tg(Mt1-RET)304Ina
Name:	transgene insertion 304, Izumi Nakashima
MGI ID:	MGI:3039777
Synonyms:	MT-ret
Transgene:	Tg(Mt1-RET)304Ina  Location: unknown
Alliance:	Tg(Mt1-RET)304Ina page

Strain of Origin:

(BALB/c x C57BL/6) X BALB/c

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(Mt1-RET)304Ina expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human RET (5979) Ret  (MGI:97902)   Mutation details: Human RET proto-oncogene cDNA driven by the mouse metallothionein 1 promoter/enhancer. This mouse is predicted to have 5 copies of the transgene. Northern blot analysis revealed high levels of transgene expression in tumors and varying levels in melanin-producing cells of other tissues in mice of this line, including skin, muscle and Harderian glands. (J:70622)

View phenotypes and curated references for all genotypes (concatenated display).

List all tumor models in MMHCdb carrying Tg(Mt1-RET)304Ina

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available

Original:	J:70622 Iwamoto T, et al., Aberrant melanogenesis and melanocytic tumour development in transgenic mice that carry a metallothionein/ret fusion gene. EMBO J. 1991 Nov;10(11):3167-75
All:	39 reference(s)