Tg(Mesp2-Dll1)4Gos
Transgene Detail
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| Symbol: |
Tg(Mesp2-Dll1)4Gos |
| Name: |
transgene insertion 4, Achim Gossler |
| MGI ID: |
MGI:3038953 |
| Synonyms: |
Mesp2::Dll1dn19 tg |
| Transgene: |
Tg(Mesp2-Dll1)4Gos Location: unknown
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| Alliance: |
Tg(Mesp2-Dll1)4Gos page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Mesp2-Dll1)4Gos expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Note |
| mouse |
Dll1 (MGI:104659) |
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Mutation details: A modified mouse Dll1 cDNA encoding a truncated protein, lacking the majority of the intracellular domain, was adjoined to 1.2 kb of the mouse Mesp2 promoter. The construct also contained an SV40 3' UTR and polyA signal. The Mesp2 promoter was expected to drive expression of the mutant Dll1 cDNA in the anterior presomitic mesoderm corresponding approximately to somitomere S-I. The mutant protein is expected to lack 141 C-terminal residues, leaving only 12 intracellular residues adjacent to the transmembrane domain.
(J:88580)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Original: |
J:88580 Cordes R, et al., Specification of vertebral identity is coupled to Notch signalling and the segmentation clock. Development. 2004 Mar;131(6):1221-33 |
| All: |
1 reference(s) |
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Analysis Tools
