Tg(SFTPC-TGFA)1Kor
Transgene Detail
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| Symbol: |
Tg(SFTPC-TGFA)1Kor |
| Name: |
transgene insertion 1, Thomas R Korfhagen |
| MGI ID: |
MGI:2389218 |
| Synonyms: |
SP-C-TGF-alpha-hGH |
| Transgene: |
Tg(SFTPC-TGFA)1Kor Location: unknown
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| Alliance: |
Tg(SFTPC-TGFA)1Kor page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(SFTPC-TGFA)1Kor expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
TGFA (7039) |
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Mutation details: The entire coding region of human TGFA was fused to the human SFTPC promoter and used for the transgene. Introns from the human growth factor gene were included to enhance transgene expression. The transgene is expressed in lung epithelial cells.
(J:79837)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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This allele is representative of several transgenic founders (H8, H9, G2, E1, 43, and 44). Founders 43 and 44 are smaller compared to age-matched littermates. Founder H9 exhibits ruffled fur and appeared lethargic at time of death.
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| Original: |
J:79837 Korfhagen TR, et al., Respiratory epithelial cell expression of human transforming growth factor-alpha induces lung fibrosis in transgenic mice. J Clin Invest. 1994 Apr;93(4):1691-9 |
| All: |
7 reference(s) |
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Analysis Tools
