Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Icmttm1Mbrg
Name:	isoprenylcysteine carboxyl methyltransferase; targeted mutation 1, Martin O Bergo
MGI ID:	MGI:3033709
Synonyms:	Icmtflx, Icmthm
Gene:	Icmt  Location: Chr4:152381684-152391578 bp, + strand  Genetic Position: Chr4, 83.02 cM
Alliance:	Icmttm1Mbrg page

Germline Transmission:	Earliest citation of germline transmission: J:88170
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Conditional ready, Hypomorph) Mutation:    Insertion   Mutation details: A floxed neomycin resistance gene was inserted upstream of exon 1 while a third loxP site was inserted in intron 1. Expression and activity levels of the encoded protein were 70 to 90% lower than controls. (J:88170)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Icmt Mutation:	11 strains or lines available

Original:	J:88170 Bergo MO, et al., Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf. J Clin Invest. 2004 Feb;113(4):539-50
All:	7 reference(s)