Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	GckRgsc552
Name:	glucokinase; RIKEN Genomic Sciences Center (GSC), 552
MGI ID:	MGI:3033230
Synonyms:	early onset diabetes, 9 RIKEN GSC, Gck9Rgsc, GckF419L, M-552, Rgcs552
Gene:	Gck  Location: Chr11:5850820-5900081 bp, - strand  Genetic Position: Chr11, 3.88 cM
Alliance:	GckRgsc552 page

Strain of Origin:	C57BL/6J
Project Collection:	RIKEN GSC ENU Project

Allele Type:    Chemically induced (ENU) Mutation:    Single point mutation   Mutation details: C to A transversion in exon 10 results in a missense mutation and substitution of leucine for phenylalanine at amino acid 419. (J:88919, J:137483) Inheritance:    Dominant

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gck Mutation:	59 strains or lines available

Original:	J:88919 Inoue M, et al., A series of maturity onset diabetes of the young, type 2 (MODY2) mouse models generated by a large-scale ENU mutagenesis program. Hum Mol Genet. 2004 Jun 1;13(11):1147-57
All:	2 reference(s)