Tg(MMTV-Catnb)5Pac
Transgene Detail
|
|
| Symbol: |
Tg(MMTV-Catnb)5Pac |
| Name: |
transgene insertion 5, Pamela Cowin |
| MGI ID: |
MGI:3029682 |
| Synonyms: |
MMTV-DeltaN89Beta-catenin |
| Transgene: |
Tg(MMTV-Catnb)5Pac Location: unknown
|
| Alliance: |
Tg(MMTV-Catnb)5Pac page
|
|
|
|
| Transgene Type: |
|
Transgenic (Inserted expressed sequence) |
| Mutation: |
|
Insertion
|
| |
|
Tg(MMTV-Catnb)5Pac expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| zebrafish |
ctnnb1 (30265) |
|
|
|
| |
|
Mutation details: To express catenin beta in the epithelium of the mammary ducts, cDNA encoding Xenopus catenin beta was adjoined to a mouse mammary tumor virus long terminal repeat. The encoded catenin beta protein lacks 89 amino terminal residues, retains cadherin/catenin binding, and has increased stability in the cytoplasmic pool. Beta globin sequence and a myc epitope tag were also included in the construct. Founder mice contained approximately 45 copies of the construct and were considered "high expressing" relative to line 3.
(J:69210)
|
|
|
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
|
| Original: |
J:69210 Imbert A, et al., Deltan89beta-catenin induces precocious development, differentiation, and neoplasia in mammary gland. J Cell Biol. 2001 Apr 30;153(3):555-68 |
| All: |
7 reference(s) |
|
Analysis Tools
