Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ltc4stm1Blam
Name:	leukotriene C4 synthase; targeted mutation 1, Bing K Lam
MGI ID:	MGI:3029254
Synonyms:	LTC4S-
Gene:	Ltc4s  Location: Chr11:50127288-50129378 bp, - strand  Genetic Position: Chr11, 30.4 cM, cytoband B1.1-B1.2
Alliance:	Ltc4stm1Blam page

Germline Transmission:	Earliest citation of germline transmission: J:87909
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin gene cassette replaced 289 nucleotides from intron 1 as well as exons 2 through 4 and 32 nucleotides from intron 4. Northern blot analysis of RNA from bone marrow macrophages confirmed the absence of normal transcripts. An exon 5 containing transcript was produced however. No leukotriene C4 was detectable. (J:87909)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ltc4s Mutation:	14 strains or lines available

Original:	J:87909 Kanaoka Y, et al., Attenuated zymosan-induced peritoneal vascular permeability and IgE-dependent passive cutaneous anaphylaxis in mice lacking leukotriene C4 synthase. J Biol Chem. 2001 Jun 22;276(25):22608-13
All:	24 reference(s)