Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pou2f2tm1Bal
Name:	POU domain, class 2, transcription factor 2; targeted mutation 1, David Baltimore
MGI ID:	MGI:3028896
Synonyms:	oct-2-
Gene:	Pou2f2  Location: Chr7:24790111-24879292 bp, - strand  Genetic Position: Chr7, 13.73 cM
Alliance:	Pou2f2tm1Bal page

Germline Transmission:	Earliest citation of germline transmission: J:4555
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Nucleotide substitutions   Mutation details: A nonsense mutation was introduced in sequence encoding the POU-specific domain via homologous recombination. The stop codon was generated upstream of the POU homeo domain, into which a PGK-neo cassette was inserted. (J:4555)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	16 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pou2f2 Mutation:	29 strains or lines available

Original:	J:4555 Corcoran LM, et al., Oct-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survival. Genes Dev. 1993 Apr;7(4):570-82
All:	12 reference(s)