Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rxfp1tm1Jgo
Name:	relaxin/insulin-like family peptide receptor 1; targeted mutation 1, Jan A Gossen
MGI ID:	MGI:3028654
Synonyms:	Lgr7-
Gene:	Rxfp1  Location: Chr3:79548918-79645187 bp, - strand  Genetic Position: Chr3, 34.94 cM
Alliance:	Rxfp1tm1Jgo page

Germline Transmission:	Earliest citation of germline transmission: J:87579
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: Part of exon 10 and all of exon 11 were replaced with a lacZ/Mc1-neomycin cassette so that lacZ was in frame. The substituted sequence encodes part of the seven transmembrane regions and the resulting protein product was no longer present in the cell membrane. (J:87579)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rxfp1 Mutation:	53 strains or lines available

Original:	J:87579 Krajnc-Franken MA, et al., Impaired nipple development and parturition in LGR7 knockout mice. Mol Cell Biol. 2004 Jan;24(2):687-96
All:	2 reference(s)