Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hcn1tm1Kndl
Name:	hyperpolarization activated cyclic nucleotide gated potassium channel 1; targeted mutation 1, Eric R Kandel
MGI ID:	MGI:2686950
Synonyms:	HCN1f
Gene:	Hcn1  Location: Chr13:117738856-118117564 bp, + strand  Genetic Position: Chr13, 66.34 cM
Alliance:	Hcn1tm1Kndl page

Germline Transmission:	Earliest citation of germline transmission: J:86763
Parent Cell Line:	MM13 (ES Cell)
Strain of Origin:	129S/SvEv

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of the pore-S6 domain containing exon. At the same time, a floxed neomycin cassette was introduced downstream. Cells in which transient Cre recombinase expression of properly targeted ES cells resulted in excision of neomycin and retention of the pore-S6 exon flanked by loxP sites were selected. (J:86763)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Hcn1 Mutation:	49 strains or lines available

Original:	J:86763 Nolan MF, et al., The hyperpolarization-activated HCN1 channel is important for motor learning and neuronal integration by cerebellar Purkinje cells. Cell. 2003 Nov 26;115(5):551-64
All:	10 reference(s)