Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Nocttm1Bjc Name: nocturnin; targeted mutation 1, J C Besharse MGI ID: MGI:2686733 Synonyms: Noc- Gene: Noct  Location: Chr3:51131868-51159065 bp, + strand  Genetic Position: Chr3, 22.12 cM, cytoband B-D Alliance: Nocttm1Bjc page

Nocttm1Bjc/Nocttm1Bjc mice exhibit a diet-dependent lean phenotype Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:122301
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The entire coding region of exon 3, which contains most of the protein coding sequence including the catalytic domain, was replaced with a neomycin resistance cassette. Absence of protein was confirmed in mutant liver homogenates. (J:122301)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Noct Mutation:	47 strains or lines available

Original:	J:122301 Green CB, et al., Loss of Nocturnin, a circadian deadenylase, confers resistance to hepatic steatosis and diet-induced obesity. Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9888-93
All:	8 reference(s)