Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ptk2tm1Lfr
Name:	PTK2 protein tyrosine kinase 2; targeted mutation 1, Louis F Reichardt
MGI ID:	MGI:2684666
Synonyms:	fak-flox, FAXloxP
Gene:	Ptk2  Location: Chr15:73076951-73295129 bp, - strand  Genetic Position: Chr15, 33.94 cM
Alliance:	Ptk2tm1Lfr page

Germline Transmission:	Earliest citation of germline transmission: J:86453
Parent Cell Line:	JM-1 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: The second kinase domain exon was flanked 5' by a loxP site and 3' by a loxP site followed by a PGK-neomycin cassette enclosed in FRT sites and in reverse orientation. The neomycin gene was eventually removed in vivo by breeding to mice expressing FlpE recombinase in the germline. (J:86453)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	11 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ptk2 Mutation:	90 strains or lines available

Original:	J:86453 Beggs HE, et al., FAK deficiency in cells contributing to the basal lamina results in cortical abnormalities resembling congenital muscular dystrophies. Neuron. 2003 Oct 30;40(3):501-14
All:	62 reference(s)