Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hcn4tm1.1Jsr
Name:	hyperpolarization-activated, cyclic nucleotide-gated K+ 4; targeted mutation 1.1, Juliane Stieber
MGI ID:	MGI:2684538
Synonyms:	Hcn4-
Gene:	Hcn4  Location: Chr9:58730695-58770458 bp, + strand  Genetic Position: Chr9, 31.8 cM, cytoband C
Alliance:	Hcn4tm1.1Jsr page

Germline Transmission:	Earliest citation of germline transmission: J:86988
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: This allele was derived from Hcn4tm1Jsr by breeding chimerics for that allele to Cre deleter mice expressing Cre in the gametes. This results in excision of exon 4 which encodes the pore region and transmembrane segment S6. Absence of protein product was demonstrated immunologically. (J:86988)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hcn4 Mutation:	67 strains or lines available

Original:	J:86988 Stieber J, et al., The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart. Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15235-40
All:	2 reference(s)