Summary | Transgene origin | Transgene description | Expression | Recombinase activity | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Tg(Pdx1-cre)89.1Dam
Name:	transgene insertion 89.1, Douglas A Melton
MGI ID:	MGI:2684317
Synonyms:	Pdx15.5-Cre, Pdx1Cre, Pdx1-Cre, Pdx1-Creearly, Pdx1-Cretg, Pdx1Tg-Cre, PDX-cre, pPdx1-Cre, Tg(Ipf1-cre)89.1Dam
Transgene:	Tg(Pdx1-cre)89.1Dam  Location: unknown
Alliance:	Tg(Pdx1-cre)89.1Dam page

Strain of Origin:

(C57BL/6 x CBA)F1

Transgene Type:    Transgenic (Recombinase) Mutation:    Insertion   Tg(Pdx1-cre)89.1Dam expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Pdx1 (MGI:102851)   Mutation details: Sequence encoding cre recombinase was adjoined to a mouse 5.5 kb region containing Pdx1 regulatory sequences. This promoter drives expression of cre recombinase in the pancreas. Expression was observed in the acini, islets, and ducts but not in mesenchymal cells (endothelial and mesenchyme-derived smooth muscle cells). Robust cre expression can be detected by E10.5 in pancreatic epithelium. (J:76095)

Activity:	Tissue activity of this recombinase allele
Driver:	Pdx1 (mouse) Summary of all recombinase alleles driven by Pdx1. Comparative matrix view of recombinase activities Alliance mouse Pdx1 gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

115 assay results 10 RNA-Seq or microarray experiment(s)

List all tumor models in MMHCdb carrying Tg(Pdx1-cre)89.1Dam

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available

Original:	J:76095 Gu G, et al., Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development. 2002 May;129(10):2447-57
All:	221 reference(s)