Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Mbd4tm2Abc
Name:	methyl-CpG binding domain protein 4; targeted mutation 2, Alfonso Bellacosa
MGI ID:	MGI:2684310
Synonyms:	delta2-5
Gene:	Mbd4  Location: Chr6:115817658-115830332 bp, - strand  Genetic Position: Chr6, 53.72 cM
Alliance:	Mbd4tm2Abc page

Germline Transmission:	Earliest citation of germline transmission: J:86981
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A genomic fragment encompassing exons 2, 3, 4, and 5 was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded portions of the 5-methylcytosine binding and catalytic domains. Transcript was undetected by RT-PCR analysis of homozygous MEFs. (J:86981)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mbd4 Mutation:	31 strains or lines available

Original:	J:86981 Cortellino S, et al., The base excision repair enzyme MED1 mediates DNA damage response to antitumor drugs and is associated with mismatch repair system integrity. Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15071-6
All:	5 reference(s)