Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mcl1tm2Sjk
Name:	myeloid cell leukemia sequence 1; targeted mutation 2, Stanley J Korsmeyer
MGI ID:	MGI:2684150
Synonyms:	Mcl1-bGeo, Mcl-1null
Gene:	Mcl1  Location: Chr3:95566099-95570487 bp, + strand  Genetic Position: Chr3, 40.74 cM
Alliance:	Mcl1tm2Sjk page

Germline Transmission:	Earliest citation of germline transmission: J:86906
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A sequence fragment extending from within exon 1 through a 5' portion of exon 2 was replaced with an IRES-betageo cassette. Western blot analysis of mutant murine embryonic fibroblasts indicated that no normal protein is produced from this allele. (J:86906)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mcl1 Mutation:	33 strains or lines available

Original:	J:86906 Opferman JT, et al., Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. Nature. 2003 Dec 11;426(6967):671-6
All:	3 reference(s)