Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sox3tm1.1Lja
Name:	SRY (sex determining region Y)-box 3; targeted mutation 1, J Larry Jameson
MGI ID:	MGI:2682663
Synonyms:	Sox3-, Sox3tm1Lja
Gene:	Sox3  Location: ChrX:59934972-59937036 bp, - strand  Genetic Position: ChrX, 33.66 cM, cytoband A7.3-B
Alliance:	Sox3tm1.1Lja page

Germline Transmission:	Earliest citation of germline transmission: J:86431
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A single loxP site remained in place of the single exon after cre mediated recombination of flanking loxP sites. A neo cassette included in the targeting vector was excised along with the endogenous sequence. (J:86431)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sox3 Mutation:	7 strains or lines available

Original:	J:86431 Weiss J, et al., Sox3 is required for gonadal function, but not sex determination, in males and females. Mol Cell Biol. 2003 Nov;23(22):8084-91
All:	4 reference(s)