Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gcnt1tm2Jxm
Name:	glucosaminyl (N-acetyl) transferase 1, core 2; targeted mutation 2, Jamey Marth
MGI ID:	MGI:2681555
Synonyms:	C2 GlcNAcTF
Gene:	Gcnt1  Location: Chr19:17303505-17350208 bp, - strand  Genetic Position: Chr19, 12.75 cM
Alliance:	Gcnt1tm2Jxm page

Germline Transmission:	Earliest citation of germline transmission: J:86387
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: The single protein coding exon was flanked upstream by a loxP site and downstream by a floxed neomycin resistance cassette. Transient Cre expression in correctly targeted cells resulted in removal of only the neomycin cassette in some ES cells. (J:86387)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gcnt1 Mutation:	29 strains or lines available

Original:	J:86387 Ellies LG, et al., Core 2 oligosaccharide biosynthesis distinguishes between selectin ligands essential for leukocyte homing and inflammation. Immunity. 1998 Dec;9(6):881-90
All:	1 reference(s)