Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Capgtm1Djk
Name:	capping actin protein, gelsolin like; targeted mutation 1, David J Kwiatkowski
MGI ID:	MGI:2680796
Synonyms:	Capg-
Gene:	Capg  Location: Chr6:72521374-72539966 bp, + strand  Genetic Position: Chr6, 32.27 cM, cytoband C3
Alliance:	Capgtm1Djk page

Germline Transmission:	Earliest citation of germline transmission: J:86517
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 7 and 8 were replaced with a neomycin selection cassette inserted by homologous recombination. Protein was undetected in homozygous mutant mice by Western blot analysis of various tissues. Further analysis of mutant bone marrow-derived macrophages using an antibody directed toward the N-terminal region confirmed the absence of truncated protein. (J:86517)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Capg Mutation:	17 strains or lines available

Original:	J:86517 Witke W, et al., Comparisons of CapG and gelsolin-null macrophages: demonstration of a unique role for CapG in receptor-mediated ruffling, phagocytosis, and vesicle rocketing. J Cell Biol. 2001 Aug 20;154(4):775-84
All:	2 reference(s)