Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Akp3tm1Jlm
Name:	alkaline phosphatase 3, intestine, not Mn requiring; targeted mutation 1, Jose Luis Millan
MGI ID:	MGI:2680530
Synonyms:	IAP-
Gene:	Akp3  Location: Chr1:87052695-87055634 bp, + strand  Genetic Position: Chr1, 44.06 cM
Alliance:	Akp3tm1Jlm page

Germline Transmission:	Earliest citation of germline transmission: J:86263
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 4 through 6 were replaced with a neomycin resistance gene. Disruption of gene expression was confirmed by RT-PCR, Northern blot, Western blot, and immunohistochemistry. (J:86263)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Akp3 Mutation:	35 strains or lines available

Original:	J:86263 Narisawa S, et al., Accelerated fat absorption in intestinal alkaline phosphatase knockout mice. Mol Cell Biol. 2003 Nov;23(21):7525-30
All:	10 reference(s)