Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Prkcetm1Ltg
Name:	protein kinase C, epsilon; targeted mutation 1, Michael Leitges
MGI ID:	MGI:2680163
Synonyms:	PKC-epsilon-
Gene:	Prkce  Location: Chr17:86475213-86965347 bp, + strand  Genetic Position: Chr17, 56.74 cM
Alliance:	Prkcetm1Ltg page

Germline Transmission:	Earliest citation of germline transmission: J:86056
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: A lacZ-neomycin cassette was inserted in exon 1 interrupting the initiation codon. Western blot analysis demonstrated the absence of gene product in homozygotes and reduced protein levels in heterozygotes. (J:86056)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

88 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prkce Mutation:	39 strains or lines available

Original:	J:86056 Wheeler DL, et al., Protein Kinase Cepsilon Is Linked to 12-O-tetradecanoylphorbol-13-acetate-induced Tumor Necrosis Factor-alpha Ectodomain Shedding and the Development of Metastatic Squamous Cell Carcinoma in Protein Kinase Cepsilon Transgenic Mice. Cancer Res. 2003 Oct 1;63(19):6547-55
All:	15 reference(s)