Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Kcnip3tm1Bux
Name:	Kv channel interacting protein 3, calsenilin; targeted mutation 1, Joseph D Buxbaum
MGI ID:	MGI:2679303
Synonyms:	dream-
Gene:	Kcnip3  Location: Chr2:127298418-127364014 bp, - strand  Genetic Position: Chr2, 62.02 cM
Alliance:	Kcnip3tm1Bux page

Germline Transmission:	Earliest citation of germline transmission: J:85927
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 2 was replaced with a cassette containing IRES-BetaGal followed by MC1-neo. Normal transcript was undetected by Northern blot analysis of RNA obtained from the brains of homozygous mutant mice. Western blot analysis indicated an absence of normal protein in homozygous mutant mice. Beta-galactosidase activity was observed in homozygous mutant mice. (J:85927)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kcnip3 Mutation:	25 strains or lines available

Original:	J:85927 Lilliehook C, et al., Altered Abeta formation and long-term potentiation in a calsenilin knock-out. J Neurosci. 2003 Oct 8;23(27):9097-106
All:	2 reference(s)