Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mnttm1.1Phu
Name:	max binding protein; targeted mutation 1.1, Peter J Hurlin
MGI ID:	MGI:2678322
Synonyms:	Mnt-
Gene:	Mnt  Location: Chr11:74721746-74736551 bp, + strand  Genetic Position: Chr11, 45.76 cM, cytoband B-C
Alliance:	Mnttm1.1Phu page

Germline Transmission:	Earliest citation of germline transmission: J:85481
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Mice heterozygous for Mnttm1Phu were crossed with transgenic mice carryingTgN(EIIa-cre)C5379Lmgd. In mice carrying both the transgene and Mnttm1Phu, cre excision removed exons 4 to 6 as well as the Hygro selection cassette. The predicted protein product would thus lack the C-terminal amino acids from residue 235 to 591. No mRNA transcripts were identified by RT-PCR in embryos homozygous for this disruption. (J:85481)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mnt Mutation:	26 strains or lines available

Original:	J:85481 Hurlin PJ, et al., Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis. EMBO J. 2003 Sep 15;22(18):4584-96
All:	2 reference(s)