Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Plk2tm1Rle
Name:	polo like kinase 2; targeted mutation 1, Raymond L Erikson
MGI ID:	MGI:2678106
Synonyms:	Plk2-
Gene:	Plk2  Location: Chr13:110531580-110537378 bp, + strand  Genetic Position: Chr13, 61.97 cM, cytoband D2.1
Alliance:	Plk2tm1Rle page

Germline Transmission:	Earliest citation of germline transmission: J:85756
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 750 bp fragment encompassing a portion of exon 1 and all of exon 2 was replaced with a neomycin selection cassette inserted by homologous recombination. Truncated transcript consisting of the neo cassette and portions of intron 2 and exon 3. The mutant transcript lacks sequence encoding the first 2 kinase domains which include the conserved putative ATP-binding pocket. Protein was undetected by Western blot analysis of homozygous mutant MEFs. (J:85756)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Plk2 Mutation:	30 strains or lines available

Original:	J:85756 Ma S, et al., Role of Plk2 (Snk) in mouse development and cell proliferation. Mol Cell Biol. 2003 Oct;23(19):6936-43
All:	1 reference(s)