Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sftpa1tm2Haw
Name:	surfactant associated protein A1; targeted mutation 2, Samuel Hawgood
MGI ID:	MGI:2677968
Synonyms:	SP-AD(-)
Gene:	Sftpa1  Location: Chr14:40853745-40858330 bp, + strand  Genetic Position: Chr14, 22.36 cM
Alliance:	Sftpa1tm2Haw page

Germline Transmission:	Earliest citation of germline transmission: J:86022
Parent Cell Line:	CB1-4 (ES Cell)
Strain of Origin:	C57BL/6J x (Rb(11.16)2H x Rb(16.17)32Lub)F1

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 2, 3, and 4, including the translation start site and short segments of flanking intronic sequence were replaced with a PGK-neo cassette. Correctly targeted ES cells were subsequently used to target Sftpd thus producing double mutant ES cells. (J:86022)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sftpa1 Mutation:	20 strains or lines available

Original:	J:86022 Hawgood S, et al., Sequential targeted deficiency of SP-A and -D leads to progressive alveolar lipoproteinosis and emphysema. Am J Physiol Lung Cell Mol Physiol. 2002 Nov;283(5):L1002-10
All:	6 reference(s)